Clinical Trials What is Diabetes? Diabetes is a disease that occurs when your blood glucose, also called blood sugar, is too high. Blood glucose is your main source of energy and comes from the food you eat. Insulina hormone made by the pancreashelps glucose from food get into your cells to be used for energy.
Diabetes is typically grouped into two main categories: In addition to gestational diabetes, which occurs during pregnancy, MODY a very rare, genetically-driven form of diabetes that does not fit well into the two main categoriesand LADA a slow-progressing subset of type 1 diabetes are also established.
Recent research has further challenged the way that we think about different diabetes types.
In particular, it appears that patients can be further classified based on key variables and that such a reclassification can help to predict the risk of complications, thereby allowing for earlier intervention and more effective treatment approaches.
The study analyzed data collected from thousands of patients recently diagnosed with diabetes. Six different variables were considered in order to reclassify the patients: A1C, BMI, age at diagnosis, estimated beta-cell function, auto-antibody status, and the degree of insulin resistance.
The results of the analysis indicated that there were five separate clusters with substantially different characteristics: Clusters 1 and 2 were characterized by low beta-cell function, young age, and low BMI.
Patients grouped in Cluster 1, but not Cluster 2, were positive for autoantibodies. Cluster 3 was characterized by a high BMI and insulin resistance, Cluster 4 was characterized by a high BMI without high insulin resistance, and Cluster 5 was comprised of a significantly older population that was otherwise similar to Cluster 4.
The average A1C levels were significantly higher in Clusters 1 and 2 as compared to Clusters 3, 4 and 5. The analysis revealed that the individuals in Cluster 3, characterized by a high BMI and insulin resistance, were more likely to develop non-alcoholic fatty liver disease as well as kidney complications compared to those with less pronounced insulin resistance Clusters 4 and 5.
Notably, this implicates insulin resistance independently of A1C in the development of complications. These results suggest that insulin-resistant patients may benefit from more intensive therapeutic intervention early on.
Strikingly, the researchers noted that Cluster 3 had the lowest percentage of patients taking Metformin; however, the analysis indicates that this group would likely benefit the most from it.
These kinds of observations highlight the need for more individualized approaches in the effort to reduce the rate of diabetes-associated complications.
The outcomes of this study underscore that diabetes is a heterogeneous disease, that diagnostics need to be more involved and that treatment strategies need to be more tailored.
The researchers believe that paying attention to more parameters can help offer more personalized treatment strategies for diabetes. Importantly, assessing these differences and the corresponding risk of complications can help facilitate earlier intensive treatment for individuals diagnosed with type 2 diabetes who are less likely to respond to more traditional treatment plans.
As medicine moves forward to become more personalized, predictive analyses for different conditions can play an important role in determining the most effective treatment approach.
The researchers note that they cannot definitively conclude that this particular diabetes stratification is optimal, nor is it known whether individuals may be able to move from one cluster to another over time.
In addition, other variables, such as blood pressure or lipid profiles are also likely to be important determinants. However, this study has taken the first steps to provide very important insight and it is clear that further investigation into these kinds of associations is warranted.Diabetes that begins in adulthood falls into five distinct categories, new research has revealed, with scientists suggesting it is time to ditch the idea that diabetes is largely split into two types.
Diabetes just got a little more complicated, or clearer, depending on your perspective.
Researchers in Scandinavia have proposed classifying diabetes as five types of disease, rather than two. Learn about the different types of diabetes and how their treatment plans differ.
Diabetes is a group of diseases in which the body either doesn’t produce enough or any insulin, or doesn’t. The main types of diabetes are classified as type 1 and type 2.
A new study, however, says that the condition should be categorized as five types. For full functionality, it is necessary to enable. The main types of diabetes are classified as type 1 and type 2.
A new study, however, says that the condition should be categorized as five types. For full functionality, it is necessary to enable. Diabetes is a chronic condition that affects millions of people across the world today. This lesson explains more about the different forms of diabetes and how they may be treated in order for a.